Assay Detail
Functional
CHEMBL643655
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Effective concentration for stimulation of [35S]GTP-gamma-S, binding to human adenosine A3 receptor
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
N6,5'-Disubstituted adenosine derivatives as partial agonists for the human adenosine A3 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 7.04 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL66393 | — | — | 1 | 7.85 |
| CHEMBL2113427 | — | — | 1 | 7.57 |
| CHEMBL464859 | NECA | — | 1 | 7.05 |
| CHEMBL388757 | N6-BENZYLADENOSINE | — | 1 | 6.42 |
| CHEMBL2113420 | — | — | 1 | 6.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL66393 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL2113427 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL464859 | NECA | EC50 | = | 89.0 | nM | 7.05 |
| CHEMBL388757 | N6-BENZYLADENOSINE | EC50 | = | 384.0 | nM | 6.42 |
| CHEMBL2113420 | — | EC50 | = | 473.0 | nM | 6.33 |