Assay Detail
Binding
CHEMBL643710
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Binding affinity for rat cortex Alpha-2 adrenergic receptor was determined using [3H]-RX 81002 binding
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and pharmacological evaluation of potent and highly selective D3 receptor ligands: inhibition of cocaine-seeking behavior and the role of dopamine D3/D2 receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.70 | 7.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL124444 | — | — | 1 | 7.27 |
| CHEMBL125916 | — | — | 1 | 7.12 |
| CHEMBL25236 | BP-897 | — | 1 | 7.08 |
| CHEMBL420510 | — | — | 1 | 7.05 |
| CHEMBL340641 | — | — | 1 | 5.98 |
| CHEMBL435218 | — | — | 1 | 5.72 |
| CHEMBL339960 | — | — | 1 | - |
| CHEMBL126889 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL124444 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL125916 | — | Ki | = | 76.0 | nM | 7.12 |
| CHEMBL25236 | BP-897 | Ki | = | 83.0 | nM | 7.08 |
| CHEMBL420510 | — | Ki | = | 89.0 | nM | 7.05 |
| CHEMBL340641 | — | Ki | = | 1047.0 | nM | 5.98 |
| CHEMBL435218 | — | Ki | = | 1887.0 | nM | 5.72 |
| CHEMBL339960 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL126889 | — | Ki | > | 10000.0 | nM | - |