Assay Detail
Binding
CHEMBL643738
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity of compound towards Alpha-1A adrenergic receptor using membranes prepared from Rat-1 fibroblasts expressing human Alpha-1A adrenergic receptor
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
alpha(1)-Adrenoceptor agonists: the identification of novel alpha(1A )subtype selective 2'-heteroaryl-2-(phenoxymethyl)imidazolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.11 | 7.56 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL13789 | — | — | 1 | 7.56 |
| CHEMBL357129 | — | — | 1 | 7.49 |
| CHEMBL143562 | — | — | 1 | 7.46 |
| CHEMBL356605 | — | — | 1 | 7.30 |
| CHEMBL420683 | — | — | 1 | 6.94 |
| CHEMBL344294 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL13789 | — | IC50 | = | 27.54 | nM | 7.56 |
| CHEMBL357129 | — | IC50 | = | 32.36 | nM | 7.49 |
| CHEMBL143562 | — | IC50 | = | 34.67 | nM | 7.46 |
| CHEMBL356605 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL420683 | — | IC50 | = | 114.82 | nM | 6.94 |
| CHEMBL344294 | — | IC50 | = | 1288.25 | nM | 5.89 |