Assay Detail
Binding
CHEMBL643744
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In vitro binding affinity against human Alpha-1A adrenergic receptor expressed in rat-1 fibroblasts cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | Fibroblast |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
2-(anilinomethyl)imidazolines as alpha1A adrenergic receptor agonists: 2'-heteroaryl and 2'-oxime ether series.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.89 | 7.45 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL155327 | — | — | 1 | 7.45 |
| CHEMBL155326 | — | — | 1 | 7.34 |
| CHEMBL154298 | — | — | 1 | 7.09 |
| CHEMBL154023 | — | — | 1 | 6.72 |
| CHEMBL156661 | — | — | 1 | 6.72 |
| CHEMBL351542 | — | — | 1 | 6.55 |
| CHEMBL117381 | — | — | 1 | 6.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL155327 | — | IC50 | = | 35.48 | nM | 7.45 |
| CHEMBL155326 | — | IC50 | = | 45.71 | nM | 7.34 |
| CHEMBL154298 | — | IC50 | = | 81.28 | nM | 7.09 |
| CHEMBL154023 | — | IC50 | = | 190.55 | nM | 6.72 |
| CHEMBL156661 | — | IC50 | = | 190.55 | nM | 6.72 |
| CHEMBL351542 | — | IC50 | = | 281.84 | nM | 6.55 |
| CHEMBL117381 | — | IC50 | = | 457.09 | nM | 6.34 |