Assay Detail
Binding
CHEMBL643745
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Concentration required for 50% inhibition of binding against Alpha-1A adrenergic receptor in human
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
2-(Anilinomethyl)imidazolines as alpha(1)-adrenoceptor agonists: the identification of alpha(1A) subtype selective 2'-carboxylic acid esters and amides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.23 | 6.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL95523 | — | — | 1 | 6.67 |
| CHEMBL319553 | — | — | 1 | 6.65 |
| CHEMBL320419 | — | — | 1 | 6.33 |
| CHEMBL421011 | — | — | 1 | 6.07 |
| CHEMBL97044 | — | — | 1 | 5.98 |
| CHEMBL450018 | — | — | 1 | 5.69 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL95523 | — | IC50 | = | 213.8 | nM | 6.67 |
| CHEMBL319553 | — | IC50 | = | 223.87 | nM | 6.65 |
| CHEMBL320419 | — | IC50 | = | 467.74 | nM | 6.33 |
| CHEMBL421011 | — | IC50 | = | 851.14 | nM | 6.07 |
| CHEMBL97044 | — | IC50 | = | 1047.13 | nM | 5.98 |
| CHEMBL450018 | — | IC50 | = | 2041.74 | nM | 5.69 |