Assay Detail
Binding
CHEMBL643746
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Displacement of [3H]prazosin from human cloned Alpha-1A adrenergic receptor
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
WB 4101-related compounds. 2. Role of the ethylene chain separating amine and phenoxy units on the affinity for alpha(1)-adrenoreceptor subtypes and 5-HT(1A) receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.13 | 9.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL25554 | — | — | 1 | 9.37 |
| CHEMBL135973 | — | — | 1 | 7.44 |
| CHEMBL134428 | — | — | 1 | 7.11 |
| CHEMBL13647 | BMY-7378 | — | 1 | 6.42 |
| CHEMBL135974 | — | — | 1 | 6.41 |
| CHEMBL132378 | — | — | 1 | 6.02 |
| CHEMBL56 | 8-OH-DPAT | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL25554 | — | Ki | = | 0.4266 | nM | 9.37 |
| CHEMBL135973 | — | Ki | = | 36.31 | nM | 7.44 |
| CHEMBL134428 | — | Ki | = | 77.62 | nM | 7.11 |
| CHEMBL13647 | BMY-7378 | Ki | = | 380.19 | nM | 6.42 |
| CHEMBL135974 | — | Ki | = | 389.05 | nM | 6.41 |
| CHEMBL132378 | — | Ki | = | 954.99 | nM | 6.02 |
| CHEMBL56 | 8-OH-DPAT | Ki | < | 1000.0 | nM | - |