Assay Detail
Binding
CHEMBL643747
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Affinity constant towards human recombinant Alpha-1A adrenergic receptor using [3H]prazosin (from CHO cells) as radioligand by radioligand binding assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
1,3-dioxolane-based ligands as a novel class of alpha1-adrenoceptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.59 | 9.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL25554 | — | — | 1 | 9.37 |
| CHEMBL286003 | — | — | 1 | 7.61 |
| CHEMBL37212 | — | — | 1 | 7.47 |
| CHEMBL37883 | — | — | 1 | 7.43 |
| CHEMBL37962 | — | — | 1 | 6.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL25554 | — | Ki | = | 0.4266 | nM | 9.37 |
| CHEMBL286003 | — | Ki | = | 24.55 | nM | 7.61 |
| CHEMBL37212 | — | Ki | = | 33.88 | nM | 7.47 |
| CHEMBL37883 | — | Ki | = | 37.15 | nM | 7.43 |
| CHEMBL37962 | — | Ki | = | 831.76 | nM | 6.08 |