Assay Detail
Binding
CHEMBL643751
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Binding affinity for human Alpha-1A adrenergic receptor from cultured LM(tk-) cells using [3H]-prazosin
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Pharmacological evaluation of UK-14,304 analogs at cloned human adrenergic receptors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 5.21 | 6.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL70676 | — | — | 1 | 6.01 |
| CHEMBL74283 | — | — | 1 | 5.95 |
| CHEMBL49137 | — | — | 1 | 5.83 |
| CHEMBL844 | BRIMONIDINE | 4.0 | 1 | 5.55 |
| CHEMBL72753 | — | — | 1 | 5.29 |
| CHEMBL74342 | — | — | 1 | 4.85 |
| CHEMBL49395 | — | — | 1 | 4.74 |
| CHEMBL73392 | — | — | 1 | 4.67 |
| CHEMBL73164 | — | — | 1 | 4.04 |
| CHEMBL72995 | — | — | 1 | - |
| CHEMBL72147 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL70676 | — | Ki | = | 977.24 | nM | 6.01 |
| CHEMBL74283 | — | Ki | = | 1122.02 | nM | 5.95 |
| CHEMBL49137 | — | Ki | = | 1479.11 | nM | 5.83 |
| CHEMBL844 | BRIMONIDINE | Ki | = | 2818.38 | nM | 5.55 |
| CHEMBL72753 | — | Ki | = | 5128.61 | nM | 5.29 |
| CHEMBL74342 | — | Ki | = | 14125.38 | nM | 4.85 |
| CHEMBL49395 | — | Ki | = | 18197.01 | nM | 4.74 |
| CHEMBL73392 | — | Ki | = | 21379.62 | nM | 4.67 |
| CHEMBL73164 | — | Ki | = | 91201.08 | nM | 4.04 |
| CHEMBL72995 | — | Ki | < | 100000.0 | nM | - |
| CHEMBL72147 | — | Ki | < | 100000.0 | nM | - |