Assay Detail
Binding
CHEMBL643754
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Binding affinity was tested on human Alpha-1A adrenergic receptor
33
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Pharmacological options in the treatment of benign prostatic hyperplasia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 33 | 8.78 | 10.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL24778 | SILODOSIN | 4.0 | 1 | 10.40 |
| CHEMBL2051956 | DEXNIGULDIPINE | 2.0 | 2 | 9.80 |
| CHEMBL25554 | — | — | 1 | 9.80 |
| CHEMBL836 | TAMSULOSIN | 4.0 | 3 | 9.70 |
| CHEMBL2 | PRAZOSIN | 4.0 | 1 | 9.70 |
| CHEMBL267336 | — | — | 1 | 9.70 |
| CHEMBL5483012 | — | — | 2 | 9.63 |
| CHEMBL25300 | — | — | 1 | 9.40 |
| CHEMBL420060 | — | — | 1 | 9.20 |
| CHEMBL88272 | — | — | 1 | 9.20 |
| CHEMBL180932 | — | — | 1 | 9.19 |
| CHEMBL25121 | — | — | 1 | 9.18 |
| CHEMBL24777 | — | — | 1 | 9.00 |
| CHEMBL278865 | UPIDOSIN | 2.0 | 1 | 9.00 |
| CHEMBL276932 | — | — | 1 | 8.90 |
| CHEMBL180561 | — | — | 1 | 8.73 |
| CHEMBL24981 | — | — | 1 | 8.60 |
| CHEMBL284103 | — | — | 1 | 8.50 |
| CHEMBL707 | DOXAZOSIN | 4.0 | 1 | 8.50 |
| CHEMBL282214 | — | — | 1 | 8.40 |
| CHEMBL279516 | INDORAMIN | 2.0 | 1 | 8.40 |
| CHEMBL284470 | — | — | 1 | 8.23 |
| CHEMBL709 | ALFUZOSIN | 4.0 | 1 | 8.00 |
| CHEMBL286591 | — | — | 1 | 7.80 |
| CHEMBL423294 | CYCLAZOSIN | — | 1 | 7.60 |
| CHEMBL25467 | — | — | 1 | 7.60 |
| CHEMBL611 | TERAZOSIN | 4.0 | 1 | 7.40 |
| CHEMBL27899 | — | — | 1 | 7.16 |
| CHEMBL543741 | — | — | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL24778 | SILODOSIN | Ki | = | 0.03981 | nM | 10.40 |
| CHEMBL2051956 | DEXNIGULDIPINE | Ki | = | 0.1585 | nM | 9.80 |
| CHEMBL25554 | — | Ki | = | 0.1585 | nM | 9.80 |
| CHEMBL836 | TAMSULOSIN | Ki | = | 0.1995 | nM | 9.70 |
| CHEMBL2051956 | DEXNIGULDIPINE | Ki | = | 0.1995 | nM | 9.70 |
| CHEMBL2 | PRAZOSIN | Ki | = | 0.1995 | nM | 9.70 |
| CHEMBL836 | TAMSULOSIN | Ki | = | 0.1995 | nM | 9.70 |
| CHEMBL267336 | — | Ki | = | 0.1995 | nM | 9.70 |
| CHEMBL5483012 | — | Ki | = | 0.2344 | nM | 9.63 |
| CHEMBL25300 | — | Ki | = | 0.3981 | nM | 9.40 |
| CHEMBL420060 | — | Ki | = | 0.631 | nM | 9.20 |
| CHEMBL88272 | — | Ki | = | 0.631 | nM | 9.20 |
| CHEMBL180932 | — | Ki | = | 0.6457 | nM | 9.19 |
| CHEMBL25121 | — | Ki | = | 0.6607 | nM | 9.18 |
| CHEMBL278865 | UPIDOSIN | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL24777 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL276932 | — | Ki | = | 1.259 | nM | 8.90 |
| CHEMBL180561 | — | Ki | = | 1.862 | nM | 8.73 |
| CHEMBL5483012 | — | Ki | = | 1.995 | nM | 8.70 |
| CHEMBL24981 | — | Ki | = | 2.512 | nM | 8.60 |
| CHEMBL284103 | — | Ki | = | 3.162 | nM | 8.50 |
| CHEMBL707 | DOXAZOSIN | Ki | = | 3.162 | nM | 8.50 |
| CHEMBL836 | TAMSULOSIN | Ki | = | 3.981 | nM | 8.40 |
| CHEMBL282214 | — | Ki | = | 3.981 | nM | 8.40 |
| CHEMBL279516 | INDORAMIN | Ki | = | 3.981 | nM | 8.40 |
| CHEMBL284470 | — | Ki | = | 5.888 | nM | 8.23 |
| CHEMBL709 | ALFUZOSIN | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL286591 | — | Ki | = | 15.85 | nM | 7.80 |
| CHEMBL25467 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL423294 | CYCLAZOSIN | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL611 | TERAZOSIN | Ki | = | 39.81 | nM | 7.40 |
| CHEMBL27899 | — | Ki | = | 69.18 | nM | 7.16 |
| CHEMBL543741 | — | Ki | = | 251.19 | nM | 6.60 |