Assay Detail
Binding
CHEMBL643755
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Binding affinity measured in CHO cells expressing human cloned Alpha-1A adrenergic receptor expressed as pKi
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Prazosin-related compounds. Effect of transforming the piperazinylquinazoline moiety into an aminomethyltetrahydroacridine system on the affinity for alpha1-adrenoreceptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.09 | 9.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL25554 | — | — | 1 | 9.37 |
| CHEMBL2 | PRAZOSIN | 4.0 | 1 | 9.23 |
| CHEMBL2112853 | — | — | 1 | 7.50 |
| CHEMBL143026 | — | — | 1 | 7.07 |
| CHEMBL144286 | — | — | 1 | 7.02 |
| CHEMBL423018 | — | — | 1 | 6.80 |
| CHEMBL145785 | — | — | 1 | 6.54 |
| CHEMBL143558 | — | — | 1 | 6.01 |
| CHEMBL144779 | — | — | 1 | 5.77 |
| CHEMBL145793 | — | — | 1 | 5.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL25554 | — | Ki | = | 0.4266 | nM | 9.37 |
| CHEMBL2 | PRAZOSIN | Ki | = | 0.5888 | nM | 9.23 |
| CHEMBL2112853 | — | Ki | = | 31.62 | nM | 7.50 |
| CHEMBL143026 | — | Ki | = | 85.11 | nM | 7.07 |
| CHEMBL144286 | — | Ki | = | 95.5 | nM | 7.02 |
| CHEMBL423018 | — | Ki | = | 158.49 | nM | 6.80 |
| CHEMBL145785 | — | Ki | = | 288.4 | nM | 6.54 |
| CHEMBL143558 | — | Ki | = | 977.24 | nM | 6.01 |
| CHEMBL144779 | — | Ki | = | 1698.24 | nM | 5.77 |
| CHEMBL145793 | — | Ki | = | 2570.4 | nM | 5.59 |