Assay Detail
Binding
CHEMBL643758
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity determined by displacement of [3H]prazosin from alpha-1A adrenergic receptor
28
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Identification of a dihydropyridine as a potent alpha1a adrenoceptor-selective antagonist that inhibits phenylephrine-induced contraction of the human prostate.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 28 | 8.30 | 9.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL91022 | — | — | 1 | 9.64 |
| CHEMBL5483012 | — | — | 1 | 9.46 |
| CHEMBL327931 | — | — | 1 | 9.28 |
| CHEMBL279436 | — | — | 3 | 9.00 |
| CHEMBL91550 | — | — | 1 | 8.97 |
| CHEMBL91415 | — | — | 1 | 8.95 |
| CHEMBL89685 | — | — | 1 | 8.93 |
| CHEMBL315914 | — | — | 1 | 8.86 |
| CHEMBL313160 | — | — | 1 | 8.83 |
| CHEMBL314960 | — | — | 1 | 8.75 |
| CHEMBL89243 | — | — | 1 | 8.74 |
| CHEMBL327712 | — | — | 1 | 8.73 |
| CHEMBL284103 | — | — | 1 | 8.35 |
| CHEMBL611 | TERAZOSIN | 4.0 | 1 | 8.16 |
| CHEMBL315538 | — | — | 1 | 8.15 |
| CHEMBL91956 | — | — | 1 | 8.06 |
| CHEMBL312871 | — | — | 1 | 8.06 |
| CHEMBL88388 | — | — | 1 | 8.05 |
| CHEMBL284470 | — | — | 1 | 7.83 |
| CHEMBL88628 | — | — | 1 | 7.79 |
| CHEMBL88448 | — | — | 1 | 7.69 |
| CHEMBL92322 | — | — | 1 | 7.44 |
| CHEMBL313953 | — | — | 1 | 7.27 |
| CHEMBL327775 | — | — | 1 | 7.25 |
| CHEMBL315392 | — | — | 1 | 7.23 |
| CHEMBL313251 | — | — | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL91022 | — | Ki | = | 0.2291 | nM | 9.64 |
| CHEMBL5483012 | — | Ki | = | 0.3467 | nM | 9.46 |
| CHEMBL327931 | — | Ki | = | 0.5248 | nM | 9.28 |
| CHEMBL279436 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL91550 | — | Ki | = | 1.072 | nM | 8.97 |
| CHEMBL91415 | — | Ki | = | 1.122 | nM | 8.95 |
| CHEMBL89685 | — | Ki | = | 1.175 | nM | 8.93 |
| CHEMBL315914 | — | Ki | = | 1.38 | nM | 8.86 |
| CHEMBL313160 | — | Ki | = | 1.479 | nM | 8.83 |
| CHEMBL314960 | — | Ki | = | 1.778 | nM | 8.75 |
| CHEMBL89243 | — | Ki | = | 1.82 | nM | 8.74 |
| CHEMBL279436 | — | Ki | = | 1.862 | nM | 8.73 |
| CHEMBL327712 | — | Ki | = | 1.862 | nM | 8.73 |
| CHEMBL284103 | — | Ki | = | 4.467 | nM | 8.35 |
| CHEMBL611 | TERAZOSIN | Ki | = | 6.918 | nM | 8.16 |
| CHEMBL315538 | — | Ki | = | 7.079 | nM | 8.15 |
| CHEMBL91956 | — | Ki | = | 8.71 | nM | 8.06 |
| CHEMBL312871 | — | Ki | = | 8.71 | nM | 8.06 |
| CHEMBL88388 | — | Ki | = | 8.913 | nM | 8.05 |
| CHEMBL284470 | — | Ki | = | 14.79 | nM | 7.83 |
| CHEMBL88628 | — | Ki | = | 16.22 | nM | 7.79 |
| CHEMBL88448 | — | Ki | = | 20.42 | nM | 7.69 |
| CHEMBL279436 | — | Ki | = | 20.89 | nM | 7.68 |
| CHEMBL92322 | — | Ki | = | 36.31 | nM | 7.44 |
| CHEMBL313953 | — | Ki | = | 53.7 | nM | 7.27 |
| CHEMBL327775 | — | Ki | = | 56.23 | nM | 7.25 |
| CHEMBL315392 | — | Ki | = | 58.88 | nM | 7.23 |
| CHEMBL313251 | — | Ki | = | 316.23 | nM | 6.50 |