Assay Detail
Binding
CHEMBL643759
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Inhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1A adrenergic receptor
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO-K1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis, pharmacology and pharmacokinetics of 3-(4-aryl-piperazin-1-ylalkyl)-uracils as uroselective alpha1A-antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 9.00 | 10.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL292189 | — | — | 1 | 10.40 |
| CHEMBL56863 | — | — | 1 | 10.20 |
| CHEMBL55695 | — | — | 1 | 9.80 |
| CHEMBL417954 | — | — | 1 | 9.60 |
| CHEMBL56331 | — | — | 1 | 9.60 |
| CHEMBL55290 | — | — | 1 | 9.50 |
| CHEMBL293149 | — | — | 1 | 9.30 |
| CHEMBL55629 | — | — | 1 | 9.10 |
| CHEMBL53675 | — | — | 1 | 9.10 |
| CHEMBL59153 | — | — | 1 | 9.00 |
| CHEMBL298838 | — | — | 1 | 9.00 |
| CHEMBL24777 | — | — | 1 | 8.90 |
| CHEMBL299452 | — | — | 1 | 8.90 |
| CHEMBL418112 | — | — | 1 | 8.80 |
| CHEMBL56489 | — | — | 1 | 8.80 |
| CHEMBL292403 | — | — | 1 | 8.70 |
| CHEMBL57740 | — | — | 1 | 8.60 |
| CHEMBL417758 | — | — | 1 | 8.40 |
| CHEMBL56375 | — | — | 1 | 8.30 |
| CHEMBL291951 | — | — | 1 | 8.20 |
| CHEMBL55645 | — | — | 1 | 8.10 |
| CHEMBL301650 | — | — | 1 | 7.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL292189 | — | Ki | = | 0.03981 | nM | 10.40 |
| CHEMBL56863 | — | Ki | = | 0.0631 | nM | 10.20 |
| CHEMBL55695 | — | Ki | = | 0.1585 | nM | 9.80 |
| CHEMBL417954 | — | Ki | = | 0.2512 | nM | 9.60 |
| CHEMBL56331 | — | Ki | = | 0.2512 | nM | 9.60 |
| CHEMBL55290 | — | Ki | = | 0.3162 | nM | 9.50 |
| CHEMBL293149 | — | Ki | = | 0.5012 | nM | 9.30 |
| CHEMBL55629 | — | Ki | = | 0.7943 | nM | 9.10 |
| CHEMBL53675 | — | Ki | = | 0.7943 | nM | 9.10 |
| CHEMBL59153 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL298838 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL24777 | — | Ki | = | 1.259 | nM | 8.90 |
| CHEMBL299452 | — | Ki | = | 1.259 | nM | 8.90 |
| CHEMBL418112 | — | Ki | = | 1.585 | nM | 8.80 |
| CHEMBL56489 | — | Ki | = | 1.585 | nM | 8.80 |
| CHEMBL292403 | — | Ki | = | 1.995 | nM | 8.70 |
| CHEMBL57740 | — | Ki | = | 2.512 | nM | 8.60 |
| CHEMBL417758 | — | Ki | = | 3.981 | nM | 8.40 |
| CHEMBL56375 | — | Ki | = | 5.012 | nM | 8.30 |
| CHEMBL291951 | — | Ki | = | 6.31 | nM | 8.20 |
| CHEMBL55645 | — | Ki | = | 7.943 | nM | 8.10 |
| CHEMBL301650 | — | Ki | = | 19.95 | nM | 7.70 |