Assay Detail
Binding
CHEMBL643760
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Binding affinity at human cloned Alpha-1A adrenergic receptor in chinese hamster ovary cells by [3H]-prazosin displacement.
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design, synthesis, and biological activity of prazosin-related antagonists. Role of the piperazine and furan units of prazosin on the selectivity for alpha1-adrenoreceptor subtypes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.85 | 9.78 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL27013 | — | — | 1 | 9.78 |
| CHEMBL341665 | — | — | 1 | 9.49 |
| CHEMBL29591 | — | — | 1 | 9.38 |
| CHEMBL2 | PRAZOSIN | 4.0 | 1 | 9.23 |
| CHEMBL13647 | BMY-7378 | — | 1 | 6.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL27013 | — | Ki | = | 0.166 | nM | 9.78 |
| CHEMBL341665 | — | Ki | = | 0.3236 | nM | 9.49 |
| CHEMBL29591 | — | Ki | = | 0.4169 | nM | 9.38 |
| CHEMBL2 | PRAZOSIN | Ki | = | 0.5888 | nM | 9.23 |
| CHEMBL13647 | BMY-7378 | Ki | = | 436.52 | nM | 6.36 |