Assay Detail
Binding
CHEMBL643772
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Stimulation of Adenylate cyclase from rat striatal membranes
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
trans-10,11-dihydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine: a highly potent selective dopamine D1 full agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.32 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL25856 | DIHYDREXIDINE | 2.0 | 1 | 7.16 |
| CHEMBL24077 | (R)-SKF-38393 | — | 1 | 7.00 |
| CHEMBL407489 | — | — | 1 | 6.16 |
| CHEMBL51017 | — | — | 1 | 6.00 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 5.30 |
| CHEMBL299430 | — | — | 1 | - |
| CHEMBL49634 | — | — | 1 | - |
| CHEMBL43345 | — | — | 1 | - |
| CHEMBL299161 | — | — | 1 | - |
| CHEMBL62 | SCH-23390 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL25856 | DIHYDREXIDINE | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL24077 | (R)-SKF-38393 | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL407489 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL51017 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL59 | DOPAMINE | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL299430 | — | IC50 | > | 10.0 | nM | - |
| CHEMBL49634 | — | IC50 | > | 10.0 | nM | - |
| CHEMBL43345 | — | IC50 | > | 10.0 | nM | - |
| CHEMBL299161 | — | IC50 | > | 10.0 | nM | - |
| CHEMBL62 | SCH-23390 | IC50 | = | - | nM | - |