Assay Detail
Binding
CHEMBL643788
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory potency against angiotensin converting enzyme by displacement of [3H]trandolaprilate binding in mouse lung
8
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
New dual inhibitors of neutral endopeptidase and angiotensin-converting enzyme: rational design, bioavailability, and pharmacological responses in experimental hypertension.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.80 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2052007 | — | — | 3 | 8.72 |
| CHEMBL2052008 | — | — | 4 | 8.35 |
| CHEMBL2051772 | — | — | 1 | 8.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2052007 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL2052008 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL2051772 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL2052007 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL2052008 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL2052007 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL2052008 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL2052008 | — | Ki | = | 95.0 | nM | 7.02 |