Assay Detail
Binding
CHEMBL643790
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Tissue | Uterus |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Balanced AT1 and AT2 angiotensin II antagonists. II. Potent 5 -hydroxyacid imidazolyl biphenyl sulfonylureas
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 7.90 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL432378 | — | — | 1 | 9.05 |
| CHEMBL314506 | — | — | 1 | 8.96 |
| CHEMBL314827 | — | — | 1 | 8.96 |
| CHEMBL89053 | — | — | 1 | 8.96 |
| CHEMBL81236 | — | — | 1 | 8.72 |
| CHEMBL315327 | — | — | 1 | 8.70 |
| CHEMBL88446 | — | — | 1 | 8.68 |
| CHEMBL316021 | — | — | 1 | 8.41 |
| CHEMBL275449 | — | — | 1 | 8.33 |
| CHEMBL89052 | — | — | 1 | 8.30 |
| CHEMBL86617 | — | — | 1 | 8.25 |
| CHEMBL89463 | — | — | 1 | 8.10 |
| CHEMBL315275 | — | — | 1 | 8.09 |
| CHEMBL313073 | — | — | 1 | 8.04 |
| CHEMBL315994 | — | — | 1 | 7.82 |
| CHEMBL89769 | — | — | 1 | 7.42 |
| CHEMBL328480 | — | — | 1 | 7.36 |
| CHEMBL330744 | — | — | 1 | 6.92 |
| CHEMBL80370 | — | — | 1 | 6.04 |
| CHEMBL313005 | — | — | 1 | 5.46 |
| CHEMBL330302 | — | — | 1 | 5.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL432378 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL314506 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL314827 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL89053 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL81236 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL315327 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL88446 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL316021 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL275449 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL89052 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL86617 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL89463 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL315275 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL313073 | — | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL315994 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL89769 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL328480 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL330744 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL80370 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL313005 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL330302 | — | IC50 | = | 3800.0 | nM | 5.42 |