Assay Detail
Binding
CHEMBL643791
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Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
21
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Tetrahydroisoquinoline derivatives with AT2-specific angiotensin II reception binding inhibitory activity
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 7.65 | 9.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL157510 | — | — | 1 | 9.24 |
| CHEMBL155836 | — | — | 2 | 9.08 |
| CHEMBL290829 | — | — | 1 | 9.05 |
| CHEMBL154057 | — | — | 1 | 8.96 |
| CHEMBL156100 | — | — | 1 | 8.72 |
| CHEMBL156129 | — | — | 1 | 8.32 |
| CHEMBL348363 | — | — | 1 | 8.24 |
| CHEMBL157946 | — | — | 1 | 8.16 |
| CHEMBL155728 | — | — | 1 | 8.03 |
| CHEMBL156165 | — | — | 1 | 7.46 |
| CHEMBL156587 | — | — | 1 | 7.40 |
| CHEMBL155987 | — | — | 1 | 7.23 |
| CHEMBL155938 | — | — | 1 | 7.16 |
| CHEMBL423236 | — | — | 1 | 6.82 |
| CHEMBL155847 | — | — | 1 | 6.77 |
| CHEMBL128416 | — | — | 1 | 6.70 |
| CHEMBL160930 | — | — | 1 | 6.43 |
| CHEMBL350875 | — | — | 1 | 6.14 |
| CHEMBL158557 | — | — | 1 | 6.12 |
| CHEMBL350220 | — | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL157510 | — | IC50 | = | 0.58 | nM | 9.24 |
| CHEMBL155836 | — | IC50 | = | 0.84 | nM | 9.08 |
| CHEMBL290829 | — | IC50 | = | 0.89 | nM | 9.05 |
| CHEMBL154057 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL156100 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL155836 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL156129 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL348363 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL157946 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL155728 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL156165 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL156587 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL155987 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL155938 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL423236 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL155847 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL128416 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL160930 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL350875 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL158557 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL350220 | — | IC50 | = | 1100.0 | nM | 5.96 |