Assay Detail
Binding
CHEMBL643794
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Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Microsome |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Balanced angiotensin II receptor antagonists. I. The effects of biphenyl ortho-substitution on AT1/AT2 affinities
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 7.44 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL294512 | — | — | 1 | 9.00 |
| CHEMBL431162 | — | — | 1 | 8.70 |
| CHEMBL60942 | — | — | 1 | 8.52 |
| CHEMBL64411 | — | — | 1 | 8.40 |
| CHEMBL304022 | — | — | 1 | 8.15 |
| CHEMBL60661 | — | — | 1 | 8.05 |
| CHEMBL61168 | — | — | 1 | 8.00 |
| CHEMBL59611 | — | — | 1 | 8.00 |
| CHEMBL431137 | — | — | 1 | 7.92 |
| CHEMBL59728 | — | — | 1 | 7.70 |
| CHEMBL417393 | — | — | 1 | 7.70 |
| CHEMBL60992 | — | — | 1 | 7.70 |
| CHEMBL294578 | — | — | 1 | 7.40 |
| CHEMBL59331 | — | — | 1 | 7.10 |
| CHEMBL61754 | — | — | 1 | 6.30 |
| CHEMBL59957 | — | — | 1 | 6.30 |
| CHEMBL59974 | — | — | 1 | 6.16 |
| CHEMBL63998 | — | — | 1 | 6.11 |
| CHEMBL61976 | — | — | 1 | 6.00 |
| CHEMBL439936 | — | — | 1 | 5.52 |
| CHEMBL443269 | — | — | 1 | - |
| CHEMBL291582 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL294512 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL431162 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL60942 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL64411 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL304022 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL60661 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL61168 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL59611 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL431137 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL59728 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL417393 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL60992 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL294578 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL59331 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL61754 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL59957 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL59974 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL63998 | — | IC50 | = | 775.0 | nM | 6.11 |
| CHEMBL61976 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL439936 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL443269 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL291582 | — | IC50 | > | 10000.0 | nM | - |