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Assay Detail

CHEMBL643795

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Compound was tested for the inhibition of angiotensin II AT2 receptor by displacement of [125I]- Ang II to rat adrenal cortical microsomes
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Type-2 angiotensin II receptor (CHEMBL257)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Balanced angiotensin II receptor antagonists. I. The effects of biphenyl ortho-substitution on AT1/AT2 affinities
Quan ML, Olson RE, Carini DJ, Ellis CD, Hillyer GL, Lalka GK, Liu J, VanAtten MK, Chiu AT, Wong PC, Wexler RR, Timmermans PB
Bioorg Med Chem Lett (1994) 4 : 2011 -2016
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 7.10 7.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL291803 1 7.10

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL291803 IC50 = 80.0 nM 7.10