Assay Detail
Binding
CHEMBL643796
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Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Midbrain |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
L-161,638: A potent AT2selective quinazolinone angiotensin II binding inhibitor
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 8.85 | 10.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL289472 | — | — | 1 | 10.22 |
| CHEMBL34082 | — | — | 1 | 9.66 |
| CHEMBL290768 | — | — | 1 | 9.62 |
| CHEMBL290669 | — | — | 1 | 9.46 |
| CHEMBL285433 | — | — | 1 | 9.34 |
| CHEMBL108981 | — | — | 1 | 9.22 |
| CHEMBL287250 | — | — | 1 | 9.15 |
| CHEMBL35324 | — | — | 1 | 9.13 |
| CHEMBL276853 | — | — | 1 | 9.00 |
| CHEMBL35638 | — | — | 1 | 9.00 |
| CHEMBL285432 | — | — | 1 | 8.85 |
| CHEMBL284123 | — | — | 1 | 8.48 |
| CHEMBL37919 | — | — | 1 | 7.48 |
| CHEMBL24322 | — | — | 1 | 5.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL289472 | — | IC50 | = | 0.06 | nM | 10.22 |
| CHEMBL34082 | — | IC50 | = | 0.22 | nM | 9.66 |
| CHEMBL290768 | — | IC50 | = | 0.24 | nM | 9.62 |
| CHEMBL290669 | — | IC50 | = | 0.35 | nM | 9.46 |
| CHEMBL285433 | — | IC50 | = | 0.46 | nM | 9.34 |
| CHEMBL108981 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL287250 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL35324 | — | IC50 | = | 0.74 | nM | 9.13 |
| CHEMBL276853 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL35638 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL285432 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL284123 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL37919 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL24322 | — | IC50 | = | 4500.0 | nM | 5.35 |