Assay Detail
Binding
CHEMBL643798
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In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Midbrain |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Imidazo[4,5-b]pyridine-based AT1 / AT2 angiotensin II receptor antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 8.10 | 9.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL304946 | — | — | 1 | 9.60 |
| CHEMBL304947 | — | — | 1 | 9.51 |
| CHEMBL68618 | — | — | 1 | 9.35 |
| CHEMBL306407 | — | — | 1 | 9.33 |
| CHEMBL302102 | — | — | 1 | 9.15 |
| CHEMBL302519 | — | — | 1 | 9.03 |
| CHEMBL71388 | — | — | 1 | 8.65 |
| CHEMBL67801 | — | — | 1 | 8.57 |
| CHEMBL308237 | — | — | 1 | 8.41 |
| CHEMBL67805 | — | — | 1 | 8.38 |
| CHEMBL67921 | — | — | 1 | 8.25 |
| CHEMBL68786 | — | — | 1 | 7.76 |
| CHEMBL306641 | — | — | 1 | 7.55 |
| CHEMBL68638 | — | — | 1 | 7.48 |
| CHEMBL308238 | — | — | 1 | 7.23 |
| CHEMBL71925 | — | — | 1 | 6.85 |
| CHEMBL307757 | — | — | 1 | 6.40 |
| CHEMBL448476 | — | — | 1 | 6.29 |
| CHEMBL71253 | — | — | 1 | 6.05 |
| CHEMBL7550 | L-158809 | — | 1 | - |
| CHEMBL296725 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL304946 | — | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL304947 | — | IC50 | = | 0.31 | nM | 9.51 |
| CHEMBL68618 | — | IC50 | = | 0.45 | nM | 9.35 |
| CHEMBL306407 | — | IC50 | = | 0.47 | nM | 9.33 |
| CHEMBL302102 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL302519 | — | IC50 | = | 0.94 | nM | 9.03 |
| CHEMBL71388 | — | IC50 | = | 2.23 | nM | 8.65 |
| CHEMBL67801 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL308237 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL67805 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL67921 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL68786 | — | IC50 | = | 17.5 | nM | 7.76 |
| CHEMBL306641 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL68638 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL308238 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL71925 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL307757 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL448476 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL71253 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL7550 | L-158809 | IC50 | > | 10000.0 | nM | - |
| CHEMBL296725 | — | IC50 | > | 10000.0 | nM | - |