Assay Detail
Binding
CHEMBL643936
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Binding affinity against cloned human adenosine A3 receptor by radioligand binding assay using [125I]-AB-MECA.
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
6-phenyl-1,4-dihydropyridine derivatives as potent and selective A3 adenosine receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 5.91 | 7.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL315168 | — | — | 1 | 7.23 |
| CHEMBL357837 | — | — | 1 | 7.14 |
| CHEMBL139931 | — | — | 1 | 6.96 |
| CHEMBL419306 | — | — | 1 | 6.70 |
| CHEMBL143938 | — | — | 1 | 6.54 |
| CHEMBL141291 | — | — | 1 | 6.48 |
| CHEMBL341839 | — | — | 1 | 6.39 |
| CHEMBL2112411 | — | — | 1 | 6.17 |
| CHEMBL344284 | — | — | 1 | 6.11 |
| CHEMBL142868 | — | — | 1 | 6.05 |
| CHEMBL143019 | — | — | 1 | 6.04 |
| CHEMBL142262 | — | — | 1 | 5.84 |
| CHEMBL337552 | — | — | 1 | 5.76 |
| CHEMBL108797 | — | — | 1 | 5.56 |
| CHEMBL108753 | — | — | 1 | 5.55 |
| CHEMBL405355 | NIGULDIPINE | 2.0 | 1 | 5.55 |
| CHEMBL2112831 | — | — | 1 | 5.50 |
| CHEMBL142226 | — | — | 1 | 5.49 |
| CHEMBL140693 | — | — | 1 | 5.38 |
| CHEMBL100071 | — | — | 1 | 5.14 |
| CHEMBL105764 | — | — | 1 | 5.07 |
| CHEMBL99744 | — | — | 1 | 4.87 |
| CHEMBL103404 | — | — | 1 | 4.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL315168 | — | Ki | = | 58.5 | nM | 7.23 |
| CHEMBL357837 | — | Ki | = | 72.4 | nM | 7.14 |
| CHEMBL139931 | — | Ki | = | 109.0 | nM | 6.96 |
| CHEMBL419306 | — | Ki | = | 198.0 | nM | 6.70 |
| CHEMBL143938 | — | Ki | = | 286.0 | nM | 6.54 |
| CHEMBL141291 | — | Ki | = | 334.0 | nM | 6.48 |
| CHEMBL341839 | — | Ki | = | 407.0 | nM | 6.39 |
| CHEMBL2112411 | — | Ki | = | 670.0 | nM | 6.17 |
| CHEMBL344284 | — | Ki | = | 785.0 | nM | 6.11 |
| CHEMBL142868 | — | Ki | = | 887.0 | nM | 6.05 |
| CHEMBL143019 | — | Ki | = | 907.0 | nM | 6.04 |
| CHEMBL142262 | — | Ki | = | 1430.0 | nM | 5.84 |
| CHEMBL337552 | — | Ki | = | 1750.0 | nM | 5.76 |
| CHEMBL108797 | — | Ki | = | 2750.0 | nM | 5.56 |
| CHEMBL108753 | — | Ki | = | 2800.0 | nM | 5.55 |
| CHEMBL405355 | NIGULDIPINE | Ki | = | 2800.0 | nM | 5.55 |
| CHEMBL2112831 | — | Ki | = | 3130.0 | nM | 5.50 |
| CHEMBL142226 | — | Ki | = | 3250.0 | nM | 5.49 |
| CHEMBL140693 | — | Ki | = | 4140.0 | nM | 5.38 |
| CHEMBL100071 | — | Ki | = | 7240.0 | nM | 5.14 |
| CHEMBL105764 | — | Ki | = | 8490.0 | nM | 5.07 |
| CHEMBL99744 | — | Ki | = | 13600.0 | nM | 4.87 |
| CHEMBL103404 | — | Ki | = | 32300.0 | nM | 4.49 |