Assay Detail
Binding
CHEMBL643946
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Binding affinity against human Alpha-1d adrenergic receptor
22
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design and synthesis of novel dihydropyridine alpha-1a antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 6.12 | 6.78 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL95548 | — | — | 1 | 6.78 |
| CHEMBL432026 | — | — | 1 | 6.61 |
| CHEMBL95434 | — | — | 1 | 6.50 |
| CHEMBL316495 | — | — | 1 | 6.42 |
| CHEMBL95263 | — | — | 1 | 6.42 |
| CHEMBL180561 | — | — | 1 | 6.40 |
| CHEMBL320736 | — | — | 1 | 6.38 |
| CHEMBL95736 | — | — | 1 | 6.36 |
| CHEMBL95253 | — | — | 1 | 6.35 |
| CHEMBL99864 | — | — | 1 | 6.34 |
| CHEMBL323579 | — | — | 4 | 6.29 |
| CHEMBL5483012 | — | — | 1 | 6.27 |
| CHEMBL100045 | — | — | 1 | 6.14 |
| CHEMBL95578 | — | — | 1 | 6.02 |
| CHEMBL95290 | — | — | 1 | 5.89 |
| CHEMBL322405 | — | — | 1 | 5.84 |
| CHEMBL330401 | — | — | 1 | 5.68 |
| CHEMBL1491 | AMLODIPINE | 4.0 | 1 | 5.27 |
| CHEMBL98038 | — | — | 1 | 4.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL95548 | — | Ki | = | 166.0 | nM | 6.78 |
| CHEMBL432026 | — | Ki | = | 246.0 | nM | 6.61 |
| CHEMBL95434 | — | Ki | = | 314.0 | nM | 6.50 |
| CHEMBL316495 | — | Ki | = | 380.0 | nM | 6.42 |
| CHEMBL95263 | — | Ki | = | 380.0 | nM | 6.42 |
| CHEMBL180561 | — | Ki | = | 398.0 | nM | 6.40 |
| CHEMBL320736 | — | Ki | = | 417.0 | nM | 6.38 |
| CHEMBL95736 | — | Ki | = | 433.0 | nM | 6.36 |
| CHEMBL95253 | — | Ki | = | 447.0 | nM | 6.35 |
| CHEMBL99864 | — | Ki | = | 454.0 | nM | 6.34 |
| CHEMBL323579 | — | Ki | = | 514.0 | nM | 6.29 |
| CHEMBL323579 | — | Ki | = | 514.0 | nM | 6.29 |
| CHEMBL5483012 | — | Ki | = | 540.0 | nM | 6.27 |
| CHEMBL100045 | — | Ki | = | 729.0 | nM | 6.14 |
| CHEMBL323579 | — | Ki | = | 893.0 | nM | 6.05 |
| CHEMBL95578 | — | Ki | = | 948.0 | nM | 6.02 |
| CHEMBL95290 | — | Ki | = | 1296.0 | nM | 5.89 |
| CHEMBL323579 | — | Ki | = | 1376.0 | nM | 5.86 |
| CHEMBL322405 | — | Ki | = | 1459.0 | nM | 5.84 |
| CHEMBL330401 | — | Ki | = | 2073.0 | nM | 5.68 |
| CHEMBL1491 | AMLODIPINE | Ki | = | 5370.0 | nM | 5.27 |
| CHEMBL98038 | — | Ki | = | 27542.0 | nM | 4.56 |