Assay Detail
Binding
CHEMBL643972
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Displacement of [125I]6-IHPP-Fsk from adenylate cyclase of bovine brain membrane
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
(Aminoalkyl)carbamates of forskolin: intermediates for the synthesis of functionalized derivatives of forskolin with different specificities for adenylyl cyclase and the glucose transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 13 | 7.25 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL326463 | — | — | 1 | 8.05 |
| CHEMBL327142 | — | — | 1 | 7.89 |
| CHEMBL52606 | COLFORSIN | 2.0 | 1 | 7.54 |
| CHEMBL328561 | — | — | 1 | 7.47 |
| CHEMBL111738 | — | — | 1 | 7.28 |
| CHEMBL111425 | — | — | 1 | 7.22 |
| CHEMBL327672 | — | — | 1 | 7.21 |
| CHEMBL326703 | — | — | 1 | 7.10 |
| CHEMBL324659 | — | — | 1 | 7.09 |
| CHEMBL322952 | — | — | 1 | 7.03 |
| CHEMBL91909 | — | — | 1 | 7.01 |
| CHEMBL324463 | — | — | 1 | 6.76 |
| CHEMBL92719 | — | — | 1 | 6.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL326463 | — | Kd | = | 9.0 | nM | 8.05 |
| CHEMBL327142 | — | Kd | = | 13.0 | nM | 7.89 |
| CHEMBL52606 | COLFORSIN | Kd | = | 29.0 | nM | 7.54 |
| CHEMBL328561 | — | Kd | = | 34.0 | nM | 7.47 |
| CHEMBL111738 | — | Kd | = | 53.0 | nM | 7.28 |
| CHEMBL111425 | — | Kd | = | 60.0 | nM | 7.22 |
| CHEMBL327672 | — | Kd | = | 61.0 | nM | 7.21 |
| CHEMBL326703 | — | Kd | = | 80.0 | nM | 7.10 |
| CHEMBL324659 | — | Kd | = | 82.0 | nM | 7.09 |
| CHEMBL322952 | — | Kd | = | 94.0 | nM | 7.03 |
| CHEMBL91909 | — | Kd | = | 98.0 | nM | 7.01 |
| CHEMBL324463 | — | Kd | = | 174.0 | nM | 6.76 |
| CHEMBL92719 | — | Kd | = | 236.0 | nM | 6.63 |