Assay Detail
Binding
CHEMBL644096
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration in vitro against rat aorta Alpha-1D adrenergic receptor;* indicates EC50 < 15% at a concentration of 10 uM
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Aorta |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
N-[3-(1H-imidazol-4-ylmethyl)phenyl]ethanesulfonamide (ABT-866, 1),(1) a novel alpha(1)-adrenoceptor ligand with an enhanced in vitro and in vivo profile relative to phenylpropanolamine and midodrine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 5.18 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1076 | DESGLYMIDODRINE | -1.0 | 1 | 5.72 |
| CHEMBL109783 | — | — | 1 | 5.58 |
| CHEMBL136560 | (1R,2S)-PHENYLPROPANOLAMINE | — | 1 | 4.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1076 | DESGLYMIDODRINE | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL109783 | — | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL136560 | (1R,2S)-PHENYLPROPANOLAMINE | EC50 | = | 58000.0 | nM | 4.24 |