Assay Detail
Binding
CHEMBL644193
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against AMPA receptor using [3H]AMPA as radioligand
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic AMPA (CHEMBL2096670) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Homo sapiens |
Publication
(3SR,4aRS,6RS,8aRS)-6-[2-(1H-tetrazol-5-yl)ethyl]decahydroisoquinoline-3 - carboxylic acid: a structurally novel, systemically active, competitive AMPA receptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.60 | 5.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL14935 | TEZAMPANEL ANHYDROUS | 2.0 | 1 | 5.87 |
| CHEMBL62809 | — | — | 1 | 5.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL14935 | TEZAMPANEL ANHYDROUS | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL62809 | — | IC50 | = | 4810.0 | nM | 5.32 |