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Assay Detail

CHEMBL644199

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory activity against porcine heart or recombinant human E-type AMPDA
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

AMP deaminase 3 (CHEMBL2912)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

AMP deaminase inhibitors. 4. Further N3-substituted coformycin aglycon analogues: N3-alkylmalonates as ribose 5'-monophosphate mimetics.
Bookser BC, Kasibhatla SR, Erion MD.
J Med Chem (2000) 43 : 1519 -1524
PubMed 10780908 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 20 5.96 7.54

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL37273 1 7.54
CHEMBL289398 1 7.40
CHEMBL288742 1 7.39
CHEMBL39940 1 6.77
CHEMBL37079 1 6.60
CHEMBL286566 1 6.44
CHEMBL39406 1 6.44
CHEMBL37278 1 6.05
CHEMBL291059 1 5.92
CHEMBL37650 1 5.89
CHEMBL287822 1 5.68
CHEMBL39386 1 5.62
CHEMBL286464 1 5.58
CHEMBL36690 1 5.38
CHEMBL290684 1 5.29
CHEMBL284858 1 5.28
CHEMBL289639 1 5.28
CHEMBL284277 1 5.22
CHEMBL288461 1 5.11
CHEMBL37325 1 4.35

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL37273 Ki = 29.0 nM 7.54
CHEMBL289398 Ki = 40.0 nM 7.40
CHEMBL288742 Ki = 41.0 nM 7.39
CHEMBL39940 Ki = 170.0 nM 6.77
CHEMBL37079 Ki = 250.0 nM 6.60
CHEMBL286566 Ki = 360.0 nM 6.44
CHEMBL39406 Ki = 360.0 nM 6.44
CHEMBL37278 Ki = 900.0 nM 6.05
CHEMBL291059 Ki = 1200.0 nM 5.92
CHEMBL37650 Ki = 1300.0 nM 5.89
CHEMBL287822 Ki = 2100.0 nM 5.68
CHEMBL39386 Ki = 2400.0 nM 5.62
CHEMBL286464 Ki = 2600.0 nM 5.58
CHEMBL36690 Ki = 4200.0 nM 5.38
CHEMBL290684 Ki = 5100.0 nM 5.29
CHEMBL284858 Ki = 5200.0 nM 5.28
CHEMBL289639 Ki = 5200.0 nM 5.28
CHEMBL284277 Ki = 6000.0 nM 5.22
CHEMBL288461 Ki = 7800.0 nM 5.11
CHEMBL37325 Ki = 44800.0 nM 4.35