Assay Detail
Binding
CHEMBL644381
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In vitro affinity for alpha adrenergic receptor by displacement of 3[H]clonidine in calf cerebral cortex
11
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Tissue | Cerebral cortex |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Expert |
Target
Cerebral cortex alpha adrenergic receptor (CHEMBL2111420) ↗| Type | PROTEIN FAMILY |
| Organism | Bos taurus |
Publication
Synthesis of (7R)-7H-indolo[3,4-gh][1,4]benzoxazines, a new class of D-heteroergolines with dopamine agonist activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.21 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL333794 | — | — | 4 | 8.15 |
| CHEMBL330997 | — | — | 1 | 7.57 |
| CHEMBL333795 | — | — | 1 | 7.51 |
| CHEMBL531 | PERGOLIDE | 4.0 | 1 | 7.39 |
| CHEMBL332337 | — | — | 1 | 7.34 |
| CHEMBL121653 | — | — | 1 | 7.26 |
| CHEMBL332546 | — | — | 1 | 6.69 |
| CHEMBL493 | BROMOCRIPTINE | 4.0 | 1 | 6.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL333794 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL333794 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL330997 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL333795 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL333794 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL531 | PERGOLIDE | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL332337 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL121653 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL332546 | — | IC50 | = | 206.0 | nM | 6.69 |
| CHEMBL493 | BROMOCRIPTINE | IC50 | = | 514.0 | nM | 6.29 |
| CHEMBL333794 | — | IC50 | = | 1354.0 | nM | 5.87 |