Assay Detail
Binding
CHEMBL644389
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards human adenosine A3 receptor expressed in HEK293 cells in presence of [125I]-AB-MECA at a concentration of 1 uM
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
1,2,4-Triazolo[4,3-a]quinoxalin-1-one: a versatile tool for the synthesis of potent and selective adenosine receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 33 | 7.08 | 8.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL16488 | — | — | 1 | 8.83 |
| CHEMBL16305 | — | — | 1 | 8.70 |
| CHEMBL280080 | — | — | 1 | 8.43 |
| CHEMBL16737 | — | — | 1 | 7.80 |
| CHEMBL274273 | — | — | 1 | 7.80 |
| CHEMBL279410 | — | — | 1 | 7.60 |
| CHEMBL276321 | — | — | 1 | 7.56 |
| CHEMBL416537 | — | — | 1 | 7.54 |
| CHEMBL16510 | — | — | 1 | 7.44 |
| CHEMBL16195 | — | — | 1 | 7.39 |
| CHEMBL279870 | — | — | 1 | 7.36 |
| CHEMBL16416 | — | — | 1 | 7.34 |
| CHEMBL273578 | — | — | 1 | 7.32 |
| CHEMBL280278 | — | — | 1 | 7.26 |
| CHEMBL16715 | — | — | 1 | 7.25 |
| CHEMBL16750 | — | — | 1 | 7.20 |
| CHEMBL16242 | — | — | 1 | 7.10 |
| CHEMBL280300 | — | — | 1 | 7.04 |
| CHEMBL276528 | — | — | 1 | 6.94 |
| CHEMBL276545 | — | — | 1 | 6.86 |
| CHEMBL16643 | — | — | 1 | 6.80 |
| CHEMBL16774 | — | — | 1 | 6.76 |
| CHEMBL16539 | — | — | 1 | 6.71 |
| CHEMBL16529 | — | — | 1 | 6.70 |
| CHEMBL16254 | — | — | 1 | 6.56 |
| CHEMBL16820 | — | — | 1 | 6.48 |
| CHEMBL16833 | — | — | 1 | 6.32 |
| CHEMBL274267 | — | — | 1 | 6.30 |
| CHEMBL422750 | — | — | 1 | 6.30 |
| CHEMBL275421 | — | — | 1 | 6.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL16488 | — | Ki | = | 1.47 | nM | 8.83 |
| CHEMBL16305 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL280080 | — | Ki | = | 3.75 | nM | 8.43 |
| CHEMBL16737 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL274273 | — | Ki | = | 15.8 | nM | 7.80 |
| CHEMBL279410 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL276321 | — | Ki | = | 27.5 | nM | 7.56 |
| CHEMBL416537 | — | Ki | = | 28.5 | nM | 7.54 |
| CHEMBL16510 | — | Ki | = | 36.6 | nM | 7.44 |
| CHEMBL16195 | — | Ki | = | 40.9 | nM | 7.39 |
| CHEMBL279870 | — | Ki | = | 44.2 | nM | 7.36 |
| CHEMBL16416 | — | Ki | = | 45.3 | nM | 7.34 |
| CHEMBL273578 | — | Ki | = | 48.3 | nM | 7.32 |
| CHEMBL280278 | — | Ki | = | 55.4 | nM | 7.26 |
| CHEMBL16715 | — | Ki | = | 56.1 | nM | 7.25 |
| CHEMBL16750 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL16242 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL280300 | — | Ki | = | 91.0 | nM | 7.04 |
| CHEMBL276528 | — | Ki | = | 114.0 | nM | 6.94 |
| CHEMBL276545 | — | Ki | = | 137.0 | nM | 6.86 |
| CHEMBL16643 | — | Ki | = | 157.0 | nM | 6.80 |
| CHEMBL16774 | — | Ki | = | 173.0 | nM | 6.76 |
| CHEMBL16539 | — | Ki | = | 197.0 | nM | 6.71 |
| CHEMBL16529 | — | Ki | = | 201.0 | nM | 6.70 |
| CHEMBL16254 | — | Ki | = | 276.0 | nM | 6.56 |
| CHEMBL16820 | — | Ki | = | 329.0 | nM | 6.48 |
| CHEMBL16833 | — | Ki | = | 479.0 | nM | 6.32 |
| CHEMBL274267 | — | Ki | = | 506.0 | nM | 6.30 |
| CHEMBL422750 | — | Ki | = | 504.0 | nM | 6.30 |
| CHEMBL275421 | — | Ki | = | 548.0 | nM | 6.26 |
| CHEMBL16215 | — | Ki | = | 960.0 | nM | 6.02 |
| CHEMBL277357 | — | Ki | = | 1246.0 | nM | 5.90 |
| CHEMBL16598 | — | Ki | = | 1700.0 | nM | 5.77 |