Assay Detail
Functional
CHEMBL644491
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Inhibition of cAMP accumulation in CHO cells expressing human adenosine A3 receptor
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists: influence of the chain at the N(8) pyrazole nitrogen.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.62 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL141550 | — | — | 1 | 8.62 |
| CHEMBL422820 | — | — | 1 | 7.86 |
| CHEMBL16687 | CGS-15943 | — | 1 | 6.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL141550 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL422820 | — | IC50 | = | 13.9 | nM | 7.86 |
| CHEMBL16687 | CGS-15943 | IC50 | = | 406.0 | nM | 6.39 |