Assay Detail
Functional
CHEMBL644503
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Inhibition of forskolin-stimulated cAMP accumulation in chinese hamster ovary cell membranes expressing human adenosine A3 receptor
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | ovary |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel amino acid derived natural products from the ascidian Atriolum robustum: identification and pharmacological characterization of a unique adenosine derivative.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.50 | 5.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL72613 | — | — | 1 | 5.17 |
| CHEMBL464859 | NECA | — | 1 | 4.18 |
| CHEMBL277041 | METHYLTHIOADENOSINE | — | 1 | 4.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL72613 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL464859 | NECA | IC50 | = | 65600.0 | nM | 4.18 |
| CHEMBL277041 | METHYLTHIOADENOSINE | IC50 | = | 71000.0 | nM | 4.15 |