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Assay Detail

CHEMBL644506

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Binding
Inhibition of human adenosine A3 receptor
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Adenosine receptor A3 (CHEMBL256)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

From hit to lead. Analyzing structure-profile relationships.
Poulain R, Horvath D, Bonnet B, Eckhoff C, Chapelain B, Bodinier MC, Déprez B.
J Med Chem (2001) 44 : 3391 -3401
PubMed 11585444 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 5.46 5.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL326538 1 5.82
CHEMBL115444 1 5.75
CHEMBL113956 1 5.61
CHEMBL333843 1 5.48
CHEMBL326263 1 5.46
CHEMBL420499 1 5.43
CHEMBL114613 1 5.43
CHEMBL115249 1 5.38
CHEMBL325516 1 5.38
CHEMBL116735 1 5.29
CHEMBL115076 1 5.26
CHEMBL116463 1 5.22

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL326538 IC50 = 1510.0 nM 5.82
CHEMBL115444 IC50 = 1780.0 nM 5.75
CHEMBL113956 IC50 = 2460.0 nM 5.61
CHEMBL333843 IC50 = 3330.0 nM 5.48
CHEMBL326263 IC50 = 3480.0 nM 5.46
CHEMBL420499 IC50 = 3730.0 nM 5.43
CHEMBL114613 IC50 = 3750.0 nM 5.43
CHEMBL115249 IC50 = 4180.0 nM 5.38
CHEMBL325516 IC50 = 4210.0 nM 5.38
CHEMBL116735 IC50 = 5080.0 nM 5.29
CHEMBL115076 IC50 = 5470.0 nM 5.26
CHEMBL116463 IC50 = 5980.0 nM 5.22