Assay Detail
Functional
CHEMBL644508
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration as antagonistic activity against cAMP generation inhibited by IB-MECA in CHO cell membranes transfected with human A3 receptor
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.02 | 8.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL138332 | — | — | 1 | 8.28 |
| CHEMBL65271 | — | — | 1 | 8.19 |
| CHEMBL422820 | — | — | 1 | 7.91 |
| CHEMBL139182 | — | — | 1 | 7.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL138332 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL65271 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL422820 | — | IC50 | = | 12.4 | nM | 7.91 |
| CHEMBL139182 | — | IC50 | = | 19.81 | nM | 7.70 |