Assay Detail
Binding
CHEMBL644555
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Binding affinity for human adenosine A3 receptor expressed in HEK293 cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Facile synthesis of fused 1,2,4-triazolo[1,5-c]pyrimidine derivatives as human adenosine A3 receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.72 | 9.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL122512 | — | — | 1 | 9.60 |
| CHEMBL123705 | — | — | 1 | 9.21 |
| CHEMBL340657 | — | — | 1 | 8.68 |
| CHEMBL332577 | — | — | 1 | 6.89 |
| CHEMBL341041 | — | — | 1 | 6.80 |
| CHEMBL340580 | — | — | 1 | 6.58 |
| CHEMBL125288 | — | — | 1 | 6.31 |
| CHEMBL126061 | — | — | 1 | - |
| CHEMBL331111 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL122512 | — | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL123705 | — | IC50 | = | 0.61 | nM | 9.21 |
| CHEMBL340657 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL332577 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL341041 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL340580 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL125288 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL126061 | — | IC50 | < | 10.0 | nM | - |
| CHEMBL331111 | — | IC50 | < | 0.1 | nM | - |