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Assay Detail

CHEMBL644595

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of aminopeptidase M or membrane leucine aminopeptidase
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Leucyl-cystinyl aminopeptidase (CHEMBL3712)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Inhibition of aminopeptidases by peptides containing ketomethylene and hydroxyethylene amide bond replacements.
Harbeson SL, Rich DH.
J Med Chem (1989) 32 : 1378 -1392
PubMed 2566685 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 2 6.53 7.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL28650 AMASTATIN 1 7.70
CHEMBL29292 UBENIMEX 2.0 1 5.36

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL28650 AMASTATIN Ki = 20.0 nM 7.70
CHEMBL29292 UBENIMEX Ki = 4400.0 nM 5.36