Assay Detail
Functional
CHEMBL644672
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Antagonistic affinity tested against isolated Rat Prostatic Vas Deferens Alpha-1A adrenergic receptor
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Vas deferens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structure-activity relationships in 1,4-benzodioxan-related compounds. 7. Selectivity of 4-phenylchroman analogues for alpha(1)-adrenoreceptor subtypes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 9 | 7.98 | 9.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL25554 | — | — | 1 | 9.51 |
| CHEMBL44403 | — | — | 1 | 9.35 |
| CHEMBL42472 | — | — | 1 | 8.88 |
| CHEMBL297106 | — | — | 1 | 8.24 |
| CHEMBL43905 | — | — | 1 | 8.21 |
| CHEMBL42558 | — | — | 1 | 7.23 |
| CHEMBL13647 | BMY-7378 | — | 1 | 7.01 |
| CHEMBL42231 | — | — | 1 | 6.75 |
| CHEMBL40325 | — | — | 1 | 6.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL25554 | — | Kd | = | 0.309 | nM | 9.51 |
| CHEMBL44403 | — | Kd | = | 0.4467 | nM | 9.35 |
| CHEMBL42472 | — | Kd | = | 1.318 | nM | 8.88 |
| CHEMBL297106 | — | Kd | = | 5.754 | nM | 8.24 |
| CHEMBL43905 | — | Kd | = | 6.166 | nM | 8.21 |
| CHEMBL42558 | — | Kd | = | 58.88 | nM | 7.23 |
| CHEMBL13647 | BMY-7378 | Kd | = | 97.72 | nM | 7.01 |
| CHEMBL42231 | — | Kd | = | 177.83 | nM | 6.75 |
| CHEMBL40325 | — | Kd | = | 208.93 | nM | 6.68 |