Assay Detail
Functional
CHEMBL644675
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Functional Alpha-1A adrenergic receptor antagonistic activity of noradrenaline induced contractions in prostatic portion of rat vas deferens
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Vas deferens |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
New potential uroselective NO-donor alpha1-antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 8.14 | 8.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL338029 | — | — | 1 | 8.64 |
| CHEMBL278865 | UPIDOSIN | 2.0 | 1 | 8.42 |
| CHEMBL338608 | — | — | 1 | 8.21 |
| CHEMBL125365 | — | — | 1 | 7.97 |
| CHEMBL125989 | — | — | 1 | 7.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL338029 | — | Kd | = | 2.291 | nM | 8.64 |
| CHEMBL278865 | UPIDOSIN | Kd | = | 3.802 | nM | 8.42 |
| CHEMBL338608 | — | Kd | = | 6.166 | nM | 8.21 |
| CHEMBL125365 | — | Kd | = | 10.72 | nM | 7.97 |
| CHEMBL125989 | — | Kd | = | 34.67 | nM | 7.46 |