Assay Detail
Binding
CHEMBL644741
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against mammalian Aminopeptidase N (APN)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and antimalarial activity of novel, quinoline-based, zinc metallo-aminopeptidase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.87 | 7.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL328470 | — | — | 1 | 7.55 |
| CHEMBL91474 | — | — | 1 | 5.87 |
| CHEMBL430903 | — | — | 1 | 5.79 |
| CHEMBL29292 | UBENIMEX | 2.0 | 1 | 5.57 |
| CHEMBL90430 | — | — | 1 | 4.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL328470 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL91474 | — | IC50 | = | 1345.0 | nM | 5.87 |
| CHEMBL430903 | — | IC50 | = | 1628.0 | nM | 5.79 |
| CHEMBL29292 | UBENIMEX | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL90430 | — | IC50 | = | 28000.0 | nM | 4.55 |