Assay Detail
Binding
CHEMBL644743
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Compound was evaluated for inhibition of enkephalin degrading enzyme, aminopeptidase N(APN)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Long lasting antinociceptive properties of enkephalin degrading enzyme (NEP and APN) inhibitor prodrugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.50 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL420321 | — | — | 1 | 8.54 |
| CHEMBL117394 | — | — | 1 | 8.32 |
| CHEMBL1160959 | — | — | 1 | 7.96 |
| CHEMBL85320 | KELATORPHAN | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL420321 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL117394 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL1160959 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL85320 | KELATORPHAN | Ki | = | 7000.0 | nM | 5.16 |