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Assay Detail

CHEMBL644747

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Binding
Inhibition against Aminopeptidase P from Escherichia coli.
15
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Escherichia coli
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Apstatin analogue inhibitors of aminopeptidase P, a bradykinin-degrading enzyme.
Maggiora LL, Orawski AT, Simmons WH.
J Med Chem (1999) 42 : 2394 -2402
PubMed 10395480 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 5.21 5.77

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2369858 1 5.77
CHEMBL311925 1 5.68
CHEMBL2369868 1 5.66
CHEMBL78505 1 5.13
CHEMBL311875 1 5.05
CHEMBL78699 1 4.80
CHEMBL79092 1 4.39
CHEMBL80368 3 -
CHEMBL79083 1 -
CHEMBL78482 1 -
CHEMBL2369857 1 -
CHEMBL81423 1 -
CHEMBL309274 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2369858 IC50 = 1700.0 nM 5.77
CHEMBL311925 IC50 = 2100.0 nM 5.68
CHEMBL2369868 IC50 = 2200.0 nM 5.66
CHEMBL78505 IC50 = 7400.0 nM 5.13
CHEMBL311875 IC50 = 9000.0 nM 5.05
CHEMBL78699 IC50 = 16000.0 nM 4.80
CHEMBL79092 IC50 = 41000.0 nM 4.39
CHEMBL80368 IC50 = 130000.0 nM -
CHEMBL79083 IC50 > 3000000.0 nM -
CHEMBL78482 IC50 > 2000000.0 nM -
CHEMBL80368 IC50 = 2000000.0 nM -
CHEMBL80368 IC50 > 2000000.0 nM -
CHEMBL2369857 IC50 = 160000.0 nM -
CHEMBL81423 IC50 = 1300000.0 nM -
CHEMBL309274 IC50 = 390000.0 nM -