Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL644748

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition against membrane bound monkey aminopeptidase P
16
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Cercopithecidae
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Xaa-Pro aminopeptidase 2 (CHEMBL4610)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Apstatin analogue inhibitors of aminopeptidase P, a bradykinin-degrading enzyme.
Maggiora LL, Orawski AT, Simmons WH.
J Med Chem (1999) 42 : 2394 -2402
PubMed 10395480 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 5.13 6.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2369868 1 6.89
CHEMBL2369858 1 6.64
CHEMBL78505 1 5.47
CHEMBL311875 1 5.21
CHEMBL311925 1 5.08
CHEMBL79083 2 4.89
CHEMBL79092 1 4.75
CHEMBL80368 3 4.68
CHEMBL81423 1 4.52
CHEMBL309274 1 4.24
CHEMBL78699 1 4.05
CHEMBL78482 1 -
CHEMBL2369857 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2369868 IC50 = 130.0 nM 6.89
CHEMBL2369858 IC50 = 230.0 nM 6.64
CHEMBL78505 IC50 = 3400.0 nM 5.47
CHEMBL311875 IC50 = 6100.0 nM 5.21
CHEMBL311925 IC50 = 8400.0 nM 5.08
CHEMBL79083 IC50 = 13000.0 nM 4.89
CHEMBL79092 IC50 = 18000.0 nM 4.75
CHEMBL80368 IC50 = 21000.0 nM 4.68
CHEMBL81423 IC50 = 30000.0 nM 4.52
CHEMBL309274 IC50 = 58000.0 nM 4.24
CHEMBL78699 IC50 = 89000.0 nM 4.05
CHEMBL79083 IC50 = 300000.0 nM -
CHEMBL78482 IC50 > 2000000.0 nM -
CHEMBL80368 IC50 > 5000000.0 nM -
CHEMBL80368 IC50 = 9000000.0 nM -
CHEMBL2369857 IC50 = 470000.0 nM -