Assay Detail
Binding
CHEMBL644805
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Ability to inhibit the binding of [3H]N6-phenylisopropyl adenosine to adenosine receptor in rat cerebral cortex membranes
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Cerebral cortex |
| Subcellular | Membrane |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Expert |
Publication
Binary drugs: conjugates of purines and a peptide that bind to both adenosine and substance P receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 7.90 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL39503 | — | — | 1 | 8.92 |
| CHEMBL37306 | — | — | 1 | 8.68 |
| CHEMBL37351 | — | — | 1 | 8.37 |
| CHEMBL606297 | — | — | 1 | 7.80 |
| CHEMBL3144091 | — | — | 1 | 7.80 |
| CHEMBL3143947 | — | — | 1 | 7.52 |
| CHEMBL3143946 | — | — | 1 | 7.46 |
| CHEMBL605246 | — | — | 1 | 6.68 |
| CHEMBL2372353 | — | — | 1 | - |
| CHEMBL2372385 | — | — | 1 | - |
| CHEMBL235363 | SUBSTANCE P | 1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL39503 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL37306 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL37351 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL606297 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL3144091 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL3143947 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL3143946 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL605246 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL2372353 | — | Ki | > | 30000.0 | nM | - |
| CHEMBL2372385 | — | Ki | > | 30000.0 | nM | - |
| CHEMBL235363 | SUBSTANCE P | Ki | > | 30000.0 | nM | - |