Assay Detail
Binding
CHEMBL644880
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory activity against aldehyde reductase 1 (ALR1) from rat kidney.
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Aldo-keto reductase family 1 member A1 (CHEMBL3871) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Novel, highly potent aldose reductase inhibitors: cyano(2-oxo-2,3-dihydroindol-3-yl)acetic acid derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.04 | 7.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL266497 | SORBINIL | 3.0 | 1 | 7.54 |
| CHEMBL33835 | — | — | 1 | 6.31 |
| CHEMBL30993 | — | — | 1 | 6.16 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 5.63 |
| CHEMBL281442 | — | — | 1 | 5.45 |
| CHEMBL284593 | — | — | 1 | 5.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL266497 | SORBINIL | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL33835 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL30993 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL50 | QUERCETIN | IC50 | = | 2320.0 | nM | 5.63 |
| CHEMBL281442 | — | IC50 | = | 3570.0 | nM | 5.45 |
| CHEMBL284593 | — | IC50 | = | 6790.0 | nM | 5.17 |