Assay Detail
Binding
CHEMBL644883
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory Activity against Human recombinant Aldose Reductase (wild type)
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL1900) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Molecular modeling of the aldose reductase-inhibitor complex based on the X-ray crystal structure and studies with single-site-directed mutants.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.04 | 7.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10372 | ZOPOLRESTAT | 2.0 | 1 | 7.44 |
| CHEMBL10413 | ZENARESTAT | 2.0 | 1 | 7.37 |
| CHEMBL436 | TOLRESTAT | 4.0 | 1 | 7.33 |
| CHEMBL269455 | IMIRESTAT | 2.0 | 1 | 7.26 |
| CHEMBL7679 | PONALRESTAT | 2.0 | 1 | 7.18 |
| CHEMBL292963 | — | — | 1 | 7.14 |
| CHEMBL10615 | — | — | 1 | 7.13 |
| CHEMBL10382 | — | — | 1 | 7.11 |
| CHEMBL10552 | — | — | 1 | 6.84 |
| CHEMBL10350 | — | — | 1 | 6.64 |
| CHEMBL266497 | SORBINIL | 3.0 | 1 | 6.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10372 | ZOPOLRESTAT | IC50 | = | 36.4 | nM | 7.44 |
| CHEMBL10413 | ZENARESTAT | IC50 | = | 42.4 | nM | 7.37 |
| CHEMBL436 | TOLRESTAT | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL269455 | IMIRESTAT | IC50 | = | 54.7 | nM | 7.26 |
| CHEMBL7679 | PONALRESTAT | IC50 | = | 66.5 | nM | 7.18 |
| CHEMBL292963 | — | IC50 | = | 72.6 | nM | 7.14 |
| CHEMBL10615 | — | IC50 | = | 73.2 | nM | 7.13 |
| CHEMBL10382 | — | IC50 | = | 78.2 | nM | 7.11 |
| CHEMBL10552 | — | IC50 | = | 144.1 | nM | 6.84 |
| CHEMBL10350 | — | IC50 | = | 226.6 | nM | 6.64 |
| CHEMBL266497 | SORBINIL | IC50 | = | 918.6 | nM | 6.04 |