Assay Detail
Binding
CHEMBL644949
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Binding affinity against Human recombinant Adenosine A3 receptor stably transfected in CHO cells using [3H]NECA as radioligand
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
N(6)-alkyl-2-alkynyl derivatives of adenosine as potent and selective agonists at the human adenosine A(3) receptor and a starting point for searching A(2B) ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 8.65 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL258535 | — | — | 1 | 9.70 |
| CHEMBL2094083 | — | — | 1 | 9.38 |
| CHEMBL261453 | — | — | 1 | 9.28 |
| CHEMBL224874 | — | — | 1 | 9.12 |
| CHEMBL2092786 | — | — | 1 | 9.12 |
| CHEMBL2092788 | — | — | 1 | 9.01 |
| CHEMBL260563 | — | — | 1 | 8.96 |
| CHEMBL410115 | — | — | 1 | 8.92 |
| CHEMBL410095 | — | — | 1 | 8.85 |
| CHEMBL262363 | — | — | 1 | 8.85 |
| CHEMBL259938 | — | — | 1 | 8.82 |
| CHEMBL2092787 | — | — | 1 | 8.64 |
| CHEMBL437842 | — | — | 1 | 8.64 |
| CHEMBL3350613 | — | — | 1 | 8.62 |
| CHEMBL2092941 | — | — | 1 | 8.48 |
| CHEMBL574597 | — | — | 1 | 8.47 |
| CHEMBL319387 | — | — | 1 | 8.33 |
| CHEMBL438418 | — | — | 1 | 8.31 |
| CHEMBL607759 | — | — | 1 | 8.31 |
| CHEMBL408918 | — | — | 1 | 8.30 |
| CHEMBL258534 | — | — | 1 | 8.26 |
| CHEMBL223270 | — | — | 1 | 8.21 |
| CHEMBL261623 | — | — | 1 | 8.01 |
| CHEMBL375190 | — | — | 1 | 7.80 |
| CHEMBL2113551 | — | — | 1 | 7.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL258535 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL2094083 | — | Ki | = | 0.42 | nM | 9.38 |
| CHEMBL261453 | — | Ki | = | 0.53 | nM | 9.28 |
| CHEMBL224874 | — | Ki | = | 0.75 | nM | 9.12 |
| CHEMBL2092786 | — | Ki | = | 0.76 | nM | 9.12 |
| CHEMBL2092788 | — | Ki | = | 0.97 | nM | 9.01 |
| CHEMBL260563 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL410115 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL410095 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL262363 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL259938 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL2092787 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL437842 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL3350613 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL2092941 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL574597 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL319387 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL438418 | — | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL607759 | — | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL408918 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL258534 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL223270 | — | Ki | = | 6.2 | nM | 8.21 |
| CHEMBL261623 | — | Ki | = | 9.7 | nM | 8.01 |
| CHEMBL375190 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL2113551 | — | Ki | = | 17.0 | nM | 7.77 |