Assay Detail
Binding
CHEMBL644952
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Binding affinity against human adenosine A3 receptor expressed on HEK293 cells using [125I]I-AB-MECA
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
New, non-adenosine, high-potency agonists for the human adenosine A2B receptor with an improved selectivity profile compared to the reference agonist N-ethylcarboxamidoadenosine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.12 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL464859 | NECA | — | 1 | 7.96 |
| CHEMBL122396 | — | — | 1 | 7.62 |
| CHEMBL125979 | — | — | 1 | 7.13 |
| CHEMBL122806 | — | — | 1 | 6.98 |
| CHEMBL124345 | — | — | 1 | 6.77 |
| CHEMBL122622 | — | — | 1 | 6.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL464859 | NECA | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL122396 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL125979 | — | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL122806 | — | Ki | = | 104.0 | nM | 6.98 |
| CHEMBL124345 | — | Ki | = | 171.0 | nM | 6.77 |
| CHEMBL122622 | — | Ki | = | 538.0 | nM | 6.27 |