Assay Detail
Binding
CHEMBL645061
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Binding affinity (Ki) at calf intestinal Adenosine deaminase
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Adenosine deaminase inhibitors. Synthesis and biological evaluation of C1' and nor-C1' derivatives of (+)-erythro-9-(2(S)-hydroxy-3(R)-nonyl)adenine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.03 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL296435 | (+)-EHNA | — | 1 | 8.70 |
| CHEMBL335918 | — | — | 1 | 7.33 |
| CHEMBL132135 | — | — | 1 | 7.25 |
| CHEMBL132985 | — | — | 1 | 6.05 |
| CHEMBL336534 | — | — | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL296435 | (+)-EHNA | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL335918 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL132135 | — | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL132985 | — | Ki | = | 890.0 | nM | 6.05 |
| CHEMBL336534 | — | Ki | = | 1600.0 | nM | 5.80 |