Assay Detail
Binding
CHEMBL645062
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Binding affinity (Ki) at calf intestinal adenosine deaminase.
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Adenosine deaminase inhibitors. Synthesis and biological evaluation of C1' and nor-C1' derivatives of (+)-erythro-9-(2(S)-hydroxy-3(R)-nonyl)adenine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.60 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50378 | EHNA | — | 1 | 8.40 |
| CHEMBL334896 | — | — | 1 | 6.50 |
| CHEMBL336735 | — | — | 1 | 6.22 |
| CHEMBL422438 | — | — | 1 | 6.00 |
| CHEMBL423163 | — | — | 1 | 5.89 |
| CHEMBL1580 | PENTOSTATIN | 4.0 | 1 | - |
| CHEMBL284483 | COFORMYCIN | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50378 | EHNA | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL334896 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL336735 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL422438 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL423163 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL1580 | PENTOSTATIN | Ki | = | 0.0025 | nM | - |
| CHEMBL284483 | COFORMYCIN | Ki | = | 1000000000.0 | nM | - |