Assay Detail
Binding
CHEMBL645063
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Binding affinity against calf intestine adenosine deaminase enzyme
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Adenosine deaminase inhibitors. Synthesis of deaza analogues of erythro-9-(2-hydroxy-3-nonyl)adenine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 6.40 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50378 | EHNA | — | 1 | 8.15 |
| CHEMBL18496 | — | — | 1 | 8.00 |
| CHEMBL329644 | — | — | 1 | 6.92 |
| CHEMBL18838 | — | — | 1 | 6.80 |
| CHEMBL96719 | — | — | 1 | 6.26 |
| CHEMBL115824 | — | — | 1 | 6.18 |
| CHEMBL321338 | — | — | 1 | 6.08 |
| CHEMBL1399702 | NEBULARINE | — | 1 | 4.82 |
| CHEMBL612139 | — | — | 1 | 4.38 |
| CHEMBL202701 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50378 | EHNA | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL18496 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL329644 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL18838 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL96719 | — | Ki | = | 550.0 | nM | 6.26 |
| CHEMBL115824 | — | Ki | = | 660.0 | nM | 6.18 |
| CHEMBL321338 | — | Ki | = | 840.0 | nM | 6.08 |
| CHEMBL1399702 | NEBULARINE | Ki | = | 15000.0 | nM | 4.82 |
| CHEMBL612139 | — | Ki | = | 42000.0 | nM | 4.38 |
| CHEMBL202701 | — | Ki | = | 360000.0 | nM | - |