Assay Detail
Binding
CHEMBL645066
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Binding affinity against Adenosine deaminase from calf intestinal mucosa was determined
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Intestinal mucosa |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
A unique ring-expanded acyclic nucleoside analogue that inhibits both adenosine deaminase (ADA) and guanine deaminase (GDA; guanase): synthesis and enzyme inhibition studies of 4,6-diamino-8H-1-hydroxyethoxymethyl-8-iminoimidazo[4,5-e][1,3]diazepine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 9.50 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1580 | PENTOSTATIN | 4.0 | 1 | 11.00 |
| CHEMBL50378 | EHNA | — | 1 | 8.00 |
| CHEMBL95745 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1580 | PENTOSTATIN | Ki | = | 0.01 | nM | 11.00 |
| CHEMBL50378 | EHNA | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL95745 | — | Ki | = | 152000.0 | nM | - |